The magnitude-7.4 quake, about 32 km deep, was centred about 24 km off the coastal town of Champerico and about 161 km southwest of Guatemala City, shaking buildings as far away as Mexico City and El Salvador.
Officials say at least 52 people have been killed.
On Thursday, President Otto Perez told media that 22 people remain unaccounted for and 200 were injured by the quake.
Crews continue to sift through the rubble looking for any signs of survivors.
This was the largest earthquake since a 1976 temblor killed 23,000 in the small Central American country.
With files from Reuters and The Associated Press