Heavy rains flooded storm drains in Espinal, located near the capital Bogota, leading water levels to reach over 3 metres high.
The worst-affected area was the Pioja River, which overflowed and swamped over 100 homes with water.
This is the third time in two weeks the area has been overtaken by flooding.
Government officials are considering a strategy to permanently relocate residents in the affected areas.
And the rain keeps flowing. Residents are in danger, along with buildings that may collapse because of the strong currents.
One flood victim said, 'What's worse is that people could be sleeping inside their home and all of a sudden it falls down on them and they won't even know what happened.'
Local officials and emergency crews are working rapidly to send food, mattresses and medications to the victims.
For the latest details on the latest on the Columbian flooding, tune into The Weather Network on TV. Your National Forecast comes up at the top and bottom of each hour.